Elisa test is the gold standard test to quantify SARS-CoV-2 antibodies, because of its sensitivity and specificity.
Serological test as ELISA/ chemiluminescence are high performance automated trials for the semi-quantitative determinatin of IgG and IgM antibodies against SARS-Cov-2 in blood samples. Its function is to detect immune response of our body. Nowadays these are the test for anibodies levels quantification anti SARS-Cov-2, because of its sensitivity and specificity.
ELISA test is performed through blood collection. Blood is analysed first of all by immunochemiluminescence technique, that defines if the patient has or not SARS-Cov-2 virus antibodies.
Once immunochemiluminescence is performed, in case it is positive, the sample is analysed to define IgG and IgM antibodies level in the body.
There is correlation between antibodies presence and protection level against the disease. However, for now there are no conclusive studies about neutralizing IgG antbodies level fo SARS-Cov-2 or about the time it remain in our body.
IgM is the first antibody produced when there is an infection, considered a marker of the acute stage of the disease.
IgG are produced later, maybe also present on the acute stage of the infection. IgG remain circulating on the blood, to protect the person against future infections.
IgM antibody can be detected approximately from the 7th day after the infection. Generally, the body produce IgG persistent antibodies from the 14th day since the infection.
|Total antibodies < 0,9
IgM < 0,9
IgG < 0,9*
|IgM > 1,1
IgG < 0,9*
|IgM > 1,1
IgG > 1,1*
|IgM < 0,9
IgG > 1,1*
|There is no antibodies presence||IgM antibodies presence||IgM and IgG antibodies presence||IgG antibodies presence|
|Not immunised||Not immunised||Immunised||Immunised|
|1.- Didn't have the infection
2.- Had the infection, but antibodies disappeared
3.- You are in window period*
|Probably infected||Recently had the infection and is in remission stage||I overcame the infection|
|If you've been in close contact with a positive case or have disease symptoms we recommend you to have a PCR test||We recommend you isolation and PCR test to confirm diagnosis||We recommend you to repeat IgG antibodies in 3 months to follow-up antibodies levels||We recommend you to repeat IgG antibodies in 3 months to follow-up antibodies levels|
Results between 0,9 and 1,1 are considered indeterminate. Probably you are in seroconversion period (antibodies levels modification). Please check with a physician to know the results. In these cases, it is recommended to repeat antibodies study in a week.
* Time period when a person is infected and that the infection can be detected (in case of COVID-19 around 10 days)
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